Clinical applications of microarray-based diagnostic tests

Clinical applications of microarray-based diagnostic tests.

Nearly 15 years have passed since the possibility of analyzing nucleic acid analytes in a massively parallel fashion was proposed using the then new concept of microarrays. A decade ago, proof of principle demonstration projects established the use of high density microarrays to genotype multiple polymorphisms within a large gene [cystic fibrosis transmembrance regulator (CFTR)], to rapidly ana...

Early diagnostic marker panel determination for microarray based clinical studies.

We present a novel, cost efficient two-phase design for predictive clinical gene expression studies: early marker panel determination (EMPD). In Phase-1, genome-wide microarrays are used only for a small number of individual patient samples. From this Phase-1 data a panel of marker genes is derived. In Phase-2, the expression values of these marker panel genes are measured for a large group of ...

STATISTICAL DEVELOPMENTS AND APPLICATIONS Diagnosing Tests: Using and Misusing Diagnostic and Screening Tests STREINER DIAGNOSTIC TESTS

Tests can be used either diagnostically (i.e., to confirm or rule out the presence of a condition in people suspected of having it) or as a screening instrument (determining who in a large group of people has the condition and often when those people are unaware of it or unwilling to admit to it). Tests that may be useful and accurate for diagnosis may actually do more harm than good when used ...

Assessing the Validity of Diagnostic Tests

Diagnostic Tests and Clinical, Laboratory and Radiological Charactersitics of COVID-19 in Pregnant Women: A Review

The emerging Coronavirus (COVID-19) is a new infectious disease and the definitive gold standard for its diagnosis in pregnancy has not yet been established. Therefore, this study was conducted with the aim of reviewing the diagnostic methods and clinical, laboratory and radiological symptoms of COVID-19 disease in pregnant women. The present study is a Narrative review. To do so, the keywords ...